A system is configured to create or enlarge a cavity in a tissue body and generally includes a cannula, a friction reduction covering, and a cavity creation member. A method of treating skin aging and similar skin disorders comprises administering retinoids in combination with erb inhibitors of the general formula 1where E1, E2, and E3 include halo, aryl is an alkylcarbonyl or alkenylcarbonyl, and alkoxy is lower alkoxy optionally substituted with amino groups. After passing through the substrate, the emitted light is focused by the lens. The compounds may be used in compositions and methods of inhibiting cell proliferation of a cancer and methods of preventing or treating cancer, including prostate cancer. The method further includes calculating a travel cost associated with travel from the origin location to each of a plurality of destination locations.