An adhesive-tape feeder includes a support plate positioned between inner walls of two support stands, and guide plates under the support plate to form a guide groove of a certain width between the guide plates and the support plate for a adhesive tape to pass through. The methods are useful for large-scale production of purified recombinant proteins from plants, plant-derived tissue or plant cells. 5 KHz to about 50 KHz may be applied to the patient’s spinal cord region from an epidural, cervical location to address at least one of high back pain, mid-back pain, low back pain, and leg pain without creating paresthesia in the patient.