A toner supply apparatus 6 is configured to be able to supply a charged toner T to a latent image forming surface LS of a photoconductor drum 3. The ESD diode is isolated from the DMOS device by a trench. The ALU implements ones complement subtraction by incorporating a subtraction select signal to invert each bit of a second operand. The prodrugs are acylated derivatives having increased aqueous solubility and cellular permeability as compared with the free hydroxamic acid, and are useful for inhibiting HDACs, and for selectively inducing terminal differentiation, cell growth arrest andor apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells.