Systems and methods for determining a characteristic of a specimen are provided. The composition comprises a compound having the formula wherein Ra is selected from \u2014OCH3, \u2014OCH2CH3, \u2014CH3, \u2014CH2CH3, \u2014CCCH3, \u2014CHCH\u2014CH3, or CH2\u2014CHCH2; and one or more anti-rheumatic agents. An IO batch includes a set of flight-overlapped IO requests of the IO requests. This helps alleviate the burden on the CPU and thereby accordingly reduce the lowering of overall system performance. The memory P well overlaps with the first OD region and the second OD region.