The instant invention provides compositions and methods for modeling post-Amadori AGE formation and the identification and characterization of effective inhibitors of post-Amadori AGE formation, and such identified inhibitor compositions. An interventional instrument is rigidly attached to a handle to prevent rotation of the instrument relative to the handle. The cartilage map can be correlated to a movement pattern of the joint to assess the affect of movement on cartilage wear. Therefore, the method provides improved time efficiency and energy efficiency as compared to existing methods for preparing gels.