This invention is the callus-removing hand piece 1 used to remove the calluses of the skin which directly causes the skin to age. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of Syk activity, which comprises administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are provided. At least a portion of the body of the metallic component is disposed in the cavity, and the head of the component is disposed on the first end of the cavity. A \u201cclick button\u201d signal is generated when a user’s hand holding the input device depresses and releases the input device against a work surface.