A mechanism is provided for determining a cause of a primary error in a complex communications topology without clockstop. The protective tube projects at least with its tip into an opening of the hollow space that is sealed off from the outside atmosphere using an elastic O-ring. The appropriate feedback position in the switched capacitor amplifier circuit is determined based on the operating region. Specifically, the invention provides a method of predicting the activation energy either for cytochrome P450-mediated hydrogen abstraction or for tetrahedral intermediate formation in cytochrome P450-aromatic hydroxylation using equations including effective atomic descriptors.