Apparatus for treating a condition of a subject is provided. The system includes a housing implantable within the host, in fluidic communication with tissue fluid indicative of a physiological regulating secretion need. Novel chemical synthetic methods to obtain polyamine analogues are disclosed, including the production of a combinatiorial polyamine library. Alternatively or additionally, a second hole is formed in an area of the platen opposite an upstream portion of the dot formation element array, and the platen guides ink, which is discarded outside an end of the recording medium when the end is printed without a margin, to the second hole. The modified microorganism may produce lactic acid at a high level under acid conditions. For example, the operator can let the left hand thereof into the main opening and let the right hand into the secondary service opening to perform a maintenance operation using both hands.