A method of controlling a physical characteristic of polymeric nanocarrier-encapsulated protein particles includes altering or selecting a weight percentage of a hydrophobic polymer block in a total amphiphilic diblock copolymer of a primary emulsion of a double emulsion, freeze-thaw technique. The timing control circuit includes a plurality of reduced swing differential signaling output terminals. The distance between each of a group of the electrodes and a virtual pole of the virtual multipole configuration is determined. A display controller superposes a standard waveform for a measured waveform, and a measured waveform for the latest cycle, so as to match a specified time phase for each waveform, and causes a display part to display these with the ultrasonic tomographic image. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.