A packet interception system intercepts message packets transmitted from a packet source or to a packet destination, and processes them so as to facilitate verification of the contents and the sequence with which the message packets are intercepted, and for storing the processed message packets for later use. The method includes the steps of providing a culture of hepatocytes, the culture having at least one bile canaliculus; exposing a candidate compound to the culture; and determining an amount of candidate compound in the at least one bile canaliculus, the amount of candidate compound in the at least one bile canaliculus indicating the susceptibility of the candidate compound to biliary excretion. The invention also provides methods for the treatment of irritable bowel syndrome and other such conditions. In response to evaluating the first packed node, the second packed node is evaluated in the DMA memory without waiting for additional copying of the second packed node from the system memory into the DMA memory. The method further includes forming a solder connection on the bonding pad. Packaging for a smoking article involves a supportive tube surrounding the smoking article and sealed in a package, where the package is made from a front and a rear sheet sealed together to form a sealed envelope.