A substantially fortified transformable blanket and jacket assembly composed of a secured union between mating and separating connection points, incorporated bundling assemblies and transport assembly for application to a pliable sheet. An insert is provided having a node securing portion and a mounting portion that is adapted to have a structural member secured thereto. If the user’s back is in contact with the backrest, the wheel chair is operative and may be controlled in a normal manner. The system includes a lid for being moved between a closed position and an open position. These methods involve administrating to or expressing in a mammal, an apoE polypeptide or nucleic acid that, when administered to or expressed in a mammal, lowers the total serum cholesterol level without inducing hypertriglyceridemia.