The present application describes to novel bicyclic hydroxamates derivatives of formula I: 1or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, B1, B2, R1, and C are defined in the present specification, which are useful as inhibitors of matrix metalloproteinases, TNF- converting enzyme, aggrecanase, or a combination thereof. Each cell includes a counterflowing absorptive media and waste water to achieve a two or three zone biomass nitratenitrite degradation environment. The interferometer is used for receiving part of the optical time-division multiplexed signal to split it into first and second signals, giving, between the first and second signals, a phase difference equivalent to one bit of the optical time-division multiplexed signal, and thereafter multiplexing the first and second signals.