The invention disclosed herein relates to methods and means for detecting and communicating andor signaling the occurrence of events, including but not limited to the satisfaction of one or more conditions. More particularly, the present invention is directed to a composition comprising camptothecin or a camptothecin-related compound and a DNA polymerase sigma inhibitor. The basis is a porous and flexible ceramic membrane which is described in PCTEP9805939. The process connector is sealed to the pressure sensor module to couple process fluid to the pressure sensor. Some embodiments include a retainer guide, having a groove therein for properly orienting the wavy section of the retainer with respect to the circuit card. The first fractal curve based filter element has first electromagnetic properties and the second fractal curve based filter element has second electromagnetic properties.