Provided herein are compounds, compositions and methods for treating disorders mediated by abnormal cellular proliferation and processes for identifying such compounds. First, the honeycomb body is configured by stacking andor winding of sheet metal layers, at least some of which are structured sheet metals layers such that the honeycomb body has channels for conducting a fluid flow. The inventive calorimeter can be produced at lower costs than those comprising a double-walled reaction vessel and allows especially IR probe analysis.