The present invention provides methods and compositions for modulating cell senescence and cell proliferation using isoforms of the p53 tumor suppressor protein. The gas generator further includes a cap arranged for displacement along the inner wall and delimiting the igniter chambe, said cap having a cylindrical peripheral wall and a radially extending cover wall. A sponge is disposed distally of the seal and absorbs fluids that enter the seal housing. The filter device can be used to ionize the ionizable interferents existed in the air, separate the ionized interferents from the other components of the air under the influence of the electric field, and discharge the interferent out of the filter device, thereby reducing the consumption of the consumables or even eliminating the need for consumables. The cable coupling is configured to attach a cable to the pipe splitting assembly.