A nucleic acid encodes a novel RNase. In particular it is directed to novel 3,4-disubstituted benzamidines and benzylamines, or a stereoisomer or pharmaceutically acceptable salt form thereof, which are useful as selective inhibitors of serine protease enzymes of the coagulation cascade; for example thrombin, factor Xa, factor XIa, factor IXa, andor factor VIIa. The embodiments of the invention can alleviate an error in a description of an image of the same contents but with a significant change in color.