A method for converting heat energy into mechanical, electrical andor thermal energy, includes two circuits which are connected one common subsection. and the binder resin contains 50% or more of vinyl polymer resin by weight based on the whole weight of the binder resin. Combined use of antisense TRPM-2 and taxanes synergistically enhances cytotoxic chemosensitivity of androgen-independent prostate cancer and in human Renal cell cancer. In addition, methods for delivering a drug to a brain through a spinal canal are described. Also described is a process for the production of an effect pigment of that kind.