The invention provides well-defined aryl andor heteroaryl substituted indoles that are useful as spingosine-1-phosphate agonists or antagonists. Multiple VSS instances are multiplexed over top of the PBTPBB infrastructure. The case includes a rotation body placed inside the case and including a rotation shaft having opposite ends rotatably supported by the rotation guide holes and a number of lobes provided in the rotation shaft at predetermined intervals. The data package may then be scheduled for on-line availability at defined times. The stopper mechanism includes a first pressing member mounted on the first member, a first biasing member for biasing the first pressing member, and an abutting surface provided on the second member for abutment of the first pressing member. The weight is connected to the rotor, and is swingable by virtue of gravity as a result of swinging of the inclined upper surface of the stand so as to drive the rotor.