1459835863-3edd2e88-81f3-4869-805e-6f9ce8b8611e

Systems and methods for synchronizing data between endpoints, including the modification of data on an endpoint without necessarily modifying data that is communicated between endpoints are disclosed. A hole is provided in the substrate, which extends from the upper surface towards the lower surface of the substrate. The crystalline calcium carbonate can be calcite that has been specially modified to a rhombohedral crystal structure with 1,0-1,1 indices.