The invention provides a novel class of pyrimidine derivatives, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of c-kit, PDGFR\u03b1 and PDGFR\u03b2 kinases. A flow collector generates flow data records based on each packet that is observed at one or more network monitoring points. An insulating collar is used to surround a portion of either the conductor or the capacitor-like structure to confine damage to the desired location. One transmission mechanism connects the movable lens barrel and the flash emitting unit with the motor, and responds to motion of the motor in a predetermined direction, to move the movable lens barrel to a photographing position and to move the flash emitting unit to the flashing position.