Spurs cause significant problems with signal detecting, amplifier gain adjustment, and signal decoding. Each key element has first and second break contacts which are decoupled for safety reasons and are commonly activated when the key element is actuated. 2 eV, an electron affinity of the hole transport material is from about 2. A method of fabricating a transistor device is also provided. The workflow execution engine is additionally configured to load and execute new or modified transitions, without reinstantiating the PE artifact, responsive to determining that at least one new or modified transitions exist. Also provided are methods for treating hypertension, which comprise administering therapeutically effective amounts of nitrosyl-cobinamide.