A semiconductor device is fabricated with a protective liner andor layer. The invention also relates to methods of treating a blood disorder in a mammal with an IL-1 inhibitor, a TNF inhibitor and an erythropoietin receptor agonist. The duct has at least a front discharge opening and side discharge ports defined in a peripheral wall for discharging a stream of cooling air induced by the cooling fan, in a direction forwardly of the engine body and in a direction slantwise forwardly of the engine body. It is preferable that both of these retardation films be placed. The first silicon containing material layer and the first semiconductor substrate region comprise different materials. At least one sharp projection extends from the outer layer into the cavity.