A wearable article comprising a dehydration indicator adapted to measure a urine ionic strength correlated to a specific gravity of the wearer’s urine and provide a visible signal when the urine ionic strength reaches a value corresponding to a predetermined threshold of the specific gravity. The inorganic layer light-emitting device exhibits high luminous efficiency through emission enhancement and improvement in light extraction efficiency. Using the PIAC rather than the occlusal or labial and buccal surfaces of the teeth for archwire shape selection promotes shaping the teeth to the shape of the jaw bone and gives consistent facial esthetics plus better retention of the treatment correction. A single VRVW-generator die can support multiple 3D-array dies. This vector makes it easy to introduce various vaccine genes from infectious viruses to the Sabin 1 poliovirus, and facilitates to produce chimeric Sabin 1 polioviruses that are expected to be powerful oral mucosal vaccines against several infectious viral diseases.