In accordance with the present method and system for improving integrated circuit layout, a local process modification is calculated from simulated process response variables at a set of control points. In one design, the flexure leg may include a first conducting layer comprising copper, a second conducting layer comprising copper, and a dielectric layer comprising a polymer disposed between the first conducting layer and the second conducting layer. Also disclosed are diagnostic methods for detecting a mutation in the human Choline Acetyltransferase nucleic acid sequence.