The subject matter of this specification can be implemented in, among other things, a system for interfacing with multiple medical imaging modalities that includes a manifest generator for generating a manifest of medical images. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. An upper threshold value and a lower threshold value are predetermined based on the brightness of the pixel of interest.