Embodiments of the present disclosure relate to methods, sensors, and systems for low power sensing. The production method also includes forming a second resist pattern film by applying a fluid resist material inside a channel groove after channel etching or inside a resist groove formed above a channel region before channel etching. A phase-frequency comparator compares first and second low frequency signals from the first and second controllable synchronous frequency dividers and outputs an adjust signal according to a detected difference therebetween. Agents that modulate the expression, phosphorylation, function and translocation of ActRII signaling pathway members also can predict agents that modulate cell adhesion, detachment, invasion and viability. When the locking pin has come out of the locking mechanism, the inner locking mechanism will let the release device return and the lock will reset, and again be ready for use when the locking pin is inserted once more.