Methods of identifying inhibitors of the fusion of two types of cells, particularly when fusion is mediated by the interaction of a viral protein and such cellular proteins as CD4 and chemokine receptors, are disclosed. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one PIM kinase. Roughness may including any disturbance of an otherwise generally smooth surface, such as grooves, indents, holes, trenches, andor the like. A video projector may project a first image comprised of first, second, and third separate images and the first separate image can be faded up to project light that is void of an image by a first command received at the communications port.