The present invention is directed generally to activating gene expression or causing over-expression of a gene by recombination methods in situ. In addition thereto, the present invention relates to the use of one ore more milk protein fractions andor one ore more milk protein preparations for inhibiting the activity of cyclooxygenase-2, in particular for the preparation of a medicament or a functional food for treating and preventing cyclooxygenase-2 mediated diseases. This etching stop layer 1 is constructed of a GaAs layer 1a, an Al0. According to this, since the decision period can be corrected to contain the sensed output of the knocking in response to the variation of the knocking occurring timing, the knocking sensing precision can be improved. A nock fits over the LEDbattery assembly and into the recess of the insert.