Provided are compounds of the formula :or a stereoisomer, tautomer, salt, hydrate or prodrug thereof that modulate tyrosine kinase activity, compositions comprising the compounds and methods of their use. The first and second frames are both composed of resin, and the first surface of the first frame is roughened. A bandwidth efficient modem in the cable network head-end increases reverse link capacity from the terminals to the head end, while bandwidth efficient modems in cable network terminals increases forward link capacity from the head end to the terminals.