A portable ice chest used for maintaining its contents in a cooled or frozen state for an extended period of time. The system comprises a bone plate, a pair of spaced-apart guides removably attached to the bone plate, and a bending tool. The motion controller drive includes a reconfigurable portion that is configurable with, for example, different communication protocols for communication with different motion controllers. The apparatus also includes a heat sink having a heat sink base for contacting the heat-generating device in order to dissipate heat produced by the device. The drilling fluid is used to create an underbalanced condition where a hydrostatic pressure in the annulus is below a zone of interest pressure. Compounds of formula III have useful properties for controlling diseases related to MC4-R action in humans including obesity and type II diabetes.