The present invention provides methods and devices for the delivery of pharmaceuticals to target tissues in situ, in vivo, ex vivo, or in vitro. The flow assembly can have a first set of blades including at least one first blade disposed within the lumen, wherein the at least one first blade extends from the housing and can be positioned between the proximal aperture and the distal aperture. A blocking member located within the body of the GFCI is adapted to be moved to a first position to blocks at least one opening of each receptacle, or to a second position to allow the prongs of a plug to enter the receptacle openings. The adjustment circuit is functionally a short transmission line, which is \u201cseen\u201d by the resonator as a reactance of a certain value. The pivoting gangway can be counterbalanced for ease of manipulation.