The invention comprises a puzzle including elements arranged in rows and columns, each element being rotatable about first and second perpendicular axes. The multimedia content may be layered using multiple different layering approaches simultaneously, and access to the different types of layers may be offered simultaneously. The membrane diffusionally limits the access of biomolecules to an enzyme, present in the hydrophilic region that catalyzes the oxidation of the biomolecule to produce hydrogen peroxide.