Novel methods for the medical treatment andor inhibition of the development of osteoporosis, breast cancer, hypercholesterolemia, hyperlipidemia or atherosclerosis in susceptible warm-blooded animals including humans involving administration of selective estrogen receptor modulator particularly compounds having the general structure: . The bulk bin is formed mainly of multiple wall corrugated board with the corrugations in a first wall oriented vertically and the corrugations in a second wall oriented horizontally. Then, the use of a result of the means which has detected the position earlier than another means shortens the position detection time. The configuration change indicator is indicative that the first configuration parameters relating to the base station are different than second configuration parameters that currently relate to the base station. An apparatus comprising a substrate having a dimension suitable as a medical or dental implant and a coating on a surface of a first coating layer derived from an alkoxide and a second coating layer that promotes osseointegration.