The subject invention provides methods andor processes for making stereoisomeric compounds of formula :wherein the variables are as defined herein, and compositions for the safe and effective treatment of various gastrointestinal disorders including, but not limited to, gastroparesis, gastroesophageal reflux and related conditions. The dual-lock type padlock is opened by either one of a key and a code. Such methods and systems can determine when a year 2000 problem exists with a particular instruction by comparing the list of instructions to be monitored with the instructions after the substituted data.