5-3–fur-2-yl-imidazolidin-2,4-dione and analogues useful as inhibitors of macrophage elastase are disclosed. According to the example embodiments, an intermediary network device or a client device dynamically manages the flow of messages received from an electronic exchange by analyzing the client device’s capabilities, such as CPU utilization. It further has been discovered that a single injection of morphogenic protein is sufficient to induce the desired biological effect, and that administration is not time-sensitive, provided mesenchymal progenitor cells are accessible to the defect site.