A method of configuring a signal booster may include receiving an indication that a first interface port of a first amplifier is configured such that external signals are not introduced to the first amplifier and measuring thermal noise output by the first amplifier at a second amplifier communicatively coupled to a second interface port of the first amplifier after receiving the indication. The circumference of a resulting cylinder being partially cut to form an opening. The MDD and hybrid detector can be used in mass spectrometry, in particular, time-of-flight mass spectrometry.