This invention is in the area of methods and compositions for the inhibition of the expression of VCAM-1 and, in particular, for the treatment of diseases mediated by VCAM-1, including cardiovascular and inflammatory diseases. The channel region includes a portion doped with an impurity to change the fixed charge density within the portion relative to a remainder of the channel region. A pressure-activated switch is provided for controlling onoff of the air pump. The food product is dispensed when the inner container is opened by removing the outer cover from the center member. By use of adjustable connections to a central disk at the top of the back strap and elastic fabrics in the straps, the shoulders are pulled rearwardly and downwardly so that the body weight is supported over the hips. The compositions exhibit an improved stability even if stored at temperatures between 5\xb0 and 40\xb0 C.