According to the invention there is provided a compound of formula I or a pharmaceutically acceptable salt or hydrate thereof; wherein the variables are as defined herein. An E-beam firing bar engages the channel and selectively engages the anvil during distal firing movements, wherein the tissue is severed and stapled driven upward from the staple cartridge to form against the anvil. This way, the substrate interacts only with a fully established, stable plasma for short times required for nanoscale processing of materials. Such transition management may be combined with using a voltage-controlled oscillator within the PLL device, which has several control inputs.