A process is provided for converting an alkane to an oxygenated product by passing an alkane gas over a first fixed bed containing a higher valence bromide salt to produce an alkyl bromide, a hydrobromic acid, and a lower valence bromide salt. Of particular interest are compositions and methods useful for the treatment of glaucoma with a reduced occurrence of hyperemia. As one example, interruptible power may be initially provided to activate or \u201cpower up\u201d an electronic device and constant power provided after the initial activation. Exemplary embodiments of a negative ESD protection clamp are disclosed where a bias circuit or a charge pump is used in place of the precharge circuit in a manner that allows the combination of the bias circuit or the charge pump together with a diode network and a cascode grounded gate snap-back NFET to provide protection against negative ESD voltage pulses.