The invention concerns substituted 1,4-di-piperidin-4-yl-piperazine derivatives having neurokinin antagonistic activity, in particular NK1 antagonistic activity, their preparation, compositions comprising them and their use as a medicine, in particular for the treatment of emesis, anxiety, depression, pain, pancreatitis and IBS. The xylose isomerase activity can complete a xylose utilization pathway so that yeast can use xylose in fermentation, such as xylose in biomass hydrolysate. The second side is opposite the first side. A correlation detecting circuit has spread-modulated fixed patterns as multiplication coefficients, and detects correlations between spread-modulated fixed patterns in received data. The mailpiece is prepared for delivery by the special service by printing information on the form necessary to comply with the special service delivery requirements.