The present invention provides novel thienopyridines, novel compositions, methods of their use, and methods of their manufacture, where such compounds of Formula 1 are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases including PTP1B, T cell PTP, . The stretching arms on both sides of the major conductor are assembled to the first rotating element and the second rotating element, respectively. A TCPIP stack is included in vmkernel.