The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said compounds. An increase value Dpm per unit time of the Spm during the usual period is estimated based upon an engine operating condition and a total amount of the Spm is determined by integration thereof. The control is operable to produce a current signal sent to the electric motor which will generate heat without significant torque. The ports are adapted to receive the laparoscopic instruments for introduction through the interior cavity and open bottom of the body into the anatomical cavity.