The invention is method for fabricating light emitting diodes. Methods for using these osteoclast-specific genes and proteins in the detection and isolation of osteoclasts, in production of antibodies specific to osteoclasts and to identify agents capable of modulating osteoclast function and treating diseases linked to osteoclasts are also provided. The holder is disposed in the shell and formed with a plurality of holes for receiving bits. Chirps transmitted by the loudspeaker travel by different paths due to reflection from TILS or thermal inversion layers at different altitudes.