A microelectromechanical resonator may include one or more resonator masses that oscillates in a bulk mode and that includes a first plurality of regions each having a density, and a second plurality of regions each having a density, the density of each of the second plurality of regions differing from the density of each of the first plurality of regions. In this process, photons of a coherent and monochromatic electromagnetic radiation of the wavelength \u03bb1 penetrate the tissue in the range between 600 and 1,200 nm and re-emerge from the tissue at differently distanced areas, then being detected with regard to frequency and number or intensity. This invention provides the vaccine above, wherein the adjuvant is saponin-based adjuvant.