A motor bridge driver interlace, implemented in an ASIC using cost-efficient CMOS technology, is designed to control four external MOS power transistors in a H-bridge configuration for DC-motor driving to achieve accurate and fast switching. The additives can optionally further comprise one or more metallic oxidants andor supports. Preferred embodiments include use of SERMs such as raloxifene, testosterone, estrogen, calcimimetics such as cinacalcet, RANKL inhibitors such as denosumab, and bisphosphonate such as risedronate.