An electrical connector assembly comprising a housing having an interior chamber defining at least one lead frame plane, and identical sets of non-identical lead frame elements. Preferably, the relatively low voltage electric field is defined by at least one unpinning shock that are lower than an expected lower limit of vulnerability as established, for example, by a defibrillation threshold test. The methods of the invention provide a rapid and cost-effective method to screen for compounds that prevent protein misfolding andor protein fibril formation andor protein aggregation which includes numerous neurodegenerative diseases including Parkinson’s disease, Alzheimer’s disease, Huntington’s disease as well as non-neuronal diseases such as type 2 diabetes. An optional capacitor my be provided in series with the series with the switch. A lever contained inside the male wall moves into and out of a slot formed in the female wall.