This invention relates to an apparatus for electron-ray deposition of a coating on an article. More particularly, the present invention provides therapeutic molecules capable of modulating signal transduction such as but not limited to cytokine-mediated signal transduction. An intersecting component is drilled, utilizing magnetic ranging techniques, from one directional section to provide a borehole intersection between the first and second boreholes, thereby connecting the subterranean path. Importantly, the present invention allows for changes to the camera viewpoint or lighting between training and test time. The invention also comprises a system that incorporates the natural relationships of patient parameters in order to use the data obtained from those parameters to non-invasively monitor a patient parameter that typically precludes direct monitoring.