The disclosure provides nucleotide analogues that comprise tetrahydrofuranyl or tetrahydrothienyl moieties with quaternary centers at the 3\u2032 position, the pharmaceutical formulations comprising the analogues, and methods of using the analogues and formulations for treating, preventing, andor inhibiting diseases or conditions associated with cancers and viruses. Corresponding ranges between images before and after switching therebetween can be displayed with the display scale fixed, such that the probability of the displayed region extending outside of the entire image is reduced and comparison of images is facilitated. The method may also include starting with booting the virtual machine in the cloud from the customer computer and continuing to boot while copying the blocks transferred during boot to cloud storage. By individually determining the traffic parameters for each vehicle and individually weighting the traffic parameters according to the strategic relevance thereof for the implementation of a specified traffic strategy, an improved implementation of the specified traffic strategy is made possible. The method comprises a first operation of dynamically identifying frequencies at which spectral nulls occur in a signal received via an optical fiber, and thereafter, segregating communications over the optical fiber into a set of inter-null bands defined by the spectral nulls. The method may further include receiving a notification about a further purchase of the user via the mobile payment service.