This invention relates to a gel formulation for nasal administration of a controlled release formulation of hormones to the systemic circulation andor to the brain. Spatial information is encoded into the spin magnetization by allowing the magnetization to evolve in a non-truncated gradient field and inducing a set of 180 degree rotations prior to signal acquisition. An impeller is rotatably positioned in the housing with paddles at a periphery thereof. A second indication may be provided to acknowledge access to the set of granted variables and allow access to be inhibited to the set of remaining variables. The computerized system comprises a parametrizable command device adapted to simulate then command a generation of the therapeutic ultra-sound waves, and to monitor the treatment by thermal MRI images.