The present invention provides for modified forms of anti-CD52 antibodies with reduced numbers of potential T-cell epitopes that are expected to display decreased immunogenicity. The sleep logbook system may acquire information associated with the sleep during periods of sleep andor during periods of wakefulness. The data decoder circuit is operable to perform a number of local iterations on a decoder input to yield a data output. In accordance with a first embodiment of the invention, a Dual Feedback-Low power regulation circuit for a three-stage power amplifier integrated circuit is provided. The software components include an application thread and an exchange thread. In particular aspects, the invention provides for the treatment of disorders characterized by the overexpression of ErbB2 utilizing the novel compounds of the invention.